Antihyperglycemic effects of hydro-ethanolic extract of Coldenia procumbens in Streptozotocin induced diabetic male albino rat

Abstract

In recent times, several synthetic drugs are available in the market to treat diabetes mellitus but none can completely cure without any side effects. Indian conventional medicine system recommended herbal therapy for the treatment of different human ailments including diabetes mellitus. In present study, hydro-ethanolic extract of whole plant of Coldenia procumbens L. was found to have potent antidiabetogenic activity that reduces fasting blood glucose level in Streptozotocin induced diabetic male Albino rat. Plant extract was administered orally by gavage at the dose of 20 mg/0.5 ml distilled water/100 gm body weight/day and 30 mg/0.5 ml distilled water/100 gm body weight/day for 14 days resulted a significant diminution of blood glucose level after 14 days. On the other hand the plant supplementation build a significant elevation of glycogen content in liver and diminution of GOT and GPT activities in liver, kidney and blood serum. STZ induced male albino rat showed damage in liver, kidney and pancreas which were recovered after the treatment of Coldenia procumbens L. for 14 days. All the described effects produced by the plant extract were compared with standard antidiabetic drug, Glibenclamide. The findings demonstrate that Coldenia procumbens L. has potential antidiabetogenic efficacy to manage type-I diabetes mellitus.