Toll like Receptors: The immunomediators of innate and acquired immunity and the targets of therapeutic concern

Abstract

Toll

â€Âlike Receptors (TLRs) are identified as pattern recognition receptors

(PRRs) present in vertebrates and invertebrates which recognize the pathogen

â€Â

associated molecular patterns (PAMPs) shared by pathogens. They are a

type of innate immune receptors, involved in the cytokine production, cellular

activation and phagocytosis of microorganisms during microbial infection.

They exist on various immune cells therefore, considered for targeted immunotherapeutic

research in current approaches. In the present review, we

have extensively discussed that how TLRs play a crucial role in mediating the innate immune response and forming a bridge between innate and adaptive

immunity. Moreover, their role in immunological disorders and treatment of

human diseases is also discussed in length.