The Immunoglobulin profiling of Schistosoma mansoni infected patients from Central India

Abstract

Schistosoma mansoni

â€Âschistosomic

immune response in them. Also, an attempt was made to correlate the observed

Ig level with the brutality of infection. Consequently, total 138

(46.9%) out of 294 volunteers were reported to have ova of

Schistosoma

mansoni

in their urine samples. Among which, 84 (28.6%) volunteers with

<50 ova in per 10 ml of urine showed light infection while remaining 54

(18.4%) volunteers with >50 ova in per 10 ml of urine showed heavy infection.

This difference was found statistically significant (X

2= 6.52, p > 0.05).

The mean immunoglobulin status observed in their serum sample were; IgE

(2141.6 ± 143.7 mg/dL), IgG (13.6 ± 3.53 mg/dL), IgA (3.72 ± 0.149 mg/dL),

IgM (2.82 ± 0.48 mg/dL) and IgD (0.12 ± 0.04 mg/dL). The relationship between

intensity of infection and serum level of IgM & IgE were positively

correlated (r =0.27 and r =0.65, respectively) while IgG, IgA and IgD were

showing negative correlation with the strength of infection (r =

â€Â0.65, r = â€Â

0.39 and r =

â€Â0.18, respectively). Therefore, IgG and IgA can be considered as

markers of light infection and IgM and IgE for heavy infection respectively.

Since, the levels of IgG, IgA and IgD were found very low in infected volunteers

than control subjects hence, are suggested to play insignificant protective

role in schistosomic infection.

, a trematode is a significant parasite of human beings

causing intestinal schistosomiasis. In the present investigation, 294 volunteers

from central India were screened for schistosomic infection, and the

serum immunoglobulin (Ig) levels were calculated as an anti