Epidemiological Characteristics of Hepatitis C Virus génotypes in East Algeria from 2011 to 2017

Abstract

In order to find the factors associated with the genotypes of patients with hepatitis C virus, namely, age, sex, wilaya (province) and risk factor, we adopted two statistical linear regression models. A total of 913 positive HCV patients were included in this study, coming from nine wilayas of eastern Algeria from 2011 to 2017. Genotype 1 was observed in 89.15% of cases with a predominance of subtype b (73.93%). According to the monovariate analy-sis, the wilaya of Constantine being associated with genotype 1b, the wilayas of Skikda, Jijel, Oum El Bouagui and Tebessa were more associated with ge-notype 2a. Since the blood transfusion factor is associated with genotype 1b, genotypes 1a, 2a and 2b were often associated with the surgical intervention factor. Age and sex variables had no influence. Multivariate analysis demons-trated that genotype 1 being associated with the wilaya of Constantine, the wilayas of Jijel, Oum-el-Bouaghi, Souk-Ahras and Skikda were respectively 4, 3, 2.5 and 10 times more likely to be associated with genotype 2. Genotype 1 being associated with the blood transfusion factor, surgical intervention (OR = 0.19, p-value = 1.1.10-7) has a 20 times greater chance of being associated with genotype 2. Genotype 1 has a 1.6-fold chance of being associated with patients with the age is over 55 years old. Both univariate and multivariate logistic regression analysis models provided useful information for the as-sessment of the distribution of genotypes of patients with HCV.