Effects of dietary fiber on glycemia and lipid profile in aging diabetic rats


  • Khayra Mebarek
  • Meryem Bensalah
  • Samira Bouanane
  • Fatima Zohra Baba Ahmed
  • Nesrine Samira Karaouzene
  • Hafida Merzouk




Dietary fiber is a group of food components which is the subject of many studies on several aspects of human health. Recent research demonstrate that dietary fiber intake is associated with reduced diabetes risk. The aim of the present work was to test the effect of dietary fiber such as cellulose and mucilage on disorders of lipid metabolism induced by experimental diabetes in the aged Wistar rats. Diabetes was induced by intraperitoneal injection of streptozotocin. Aging male Wistar rats diabetic and control rats were fed highly-pure-cellulose-mucilage-enriched (HPCME) diet or control diet for 2 months. At the end of study, blood samples and tissue are collected for de-termination of biochemical parameters (glucose, total cholesterol, triglycer-ides and lipoproteins) and lipases activities. 2 months of HPCME diet intake by diabetic aged rats improves diabetic control, induced a decrease of body weight, a reduction of plasma lipid concentration, lower blood-glucose and a significant decrease in expression of pathway lipolytic enzyme activities va-lues witch decrease the prevalence of the specific disorders of diabetes. This study suggests that dietary fiber (HPCME), has an important physiological effect on glucose and lipid metabolism during aging which reduces the risk of developing complications of diabetes.






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