Protective effects of vitamin E on aluminium chloride-induced liver and kidney damage in rats

Abstract

Aluminium is present in many manufactured foods and medicines and is also used in water purification. It is known that aluminium causes oxidative stress. Therefore, the present study was undertaken to determine the effectiveness of vitamin E (VE) in modulating the toxicity of aluminium chloride (AlCl3) on biochemical parameters, antioxidant enzymes and lipid peroxidation in serum and different organs (liver and kidney) of male Wistar rats. 24 rats (150-180g) were divided into four groups of six animals each : control ; Al was administered intraperitoneally (50 mg/kg/bw, one times a week) ; VE was given orally at a daily dose (100 mg/kg/bw) and Al+VE group. The experiment during for 90 days. AlCl3 caused a decreased in body weight consumption along with increased in the absolute and relative liver and kidney weights. TBARS level was increased, and the enzymes activities of CAT and SOD were decreased in liver and kidney of rats treated with AlCl3. While, TBARS was decreased and the antioxidant enzymes were increased in rats treated with VE. The hepatic and renal damage induced by Al was evidenced by a increase in the levels of serum AST, ALT, LDH, ALP, γGT, glucose, urea, creatinine and bilirubin, while total protein and albumin were decreased due to AlCl3 administration. These parameters indicated the extent of oxidative damage in liver and kidney, thus confirming the histology results in these organs. It can be concluded in this study that presence of VE effectively atte-nuated AlCl3 induced hepatotoxicity and nephrotoxicity in rats. It has benefi-cial influences and protective effect against AlCl3 toxicity.