Platelet aggregation inhibitory activity and radical scavenging activity of Spondias mangifera Willd

Abstract

The dry powder of Spondias mangifera Willd. fruits was sequentially extracted with hexane, chloroform, ethyl acetate, acetone and methanol. The extract yield increased with increase in the polarity of the solvent. The ethyl acetate extract showed potential platelet aggregation inhibitory activity with IC50 value of 0.33 mg and 0.43 mg for antagonists like collagen and ADP respectively. The methanol extract also revealed high platelet aggregation inhibition with very low IC50 value of 0.26 mg and 0.35 mg for antagonists like collagen and ADP respectively. Methanol extract showed high DPPH radical scavenging activity compared to other extracts.