Impact of environments factors in reproductive function: Protective effect of cinnamon against the mercury chloride induced toxicity in female Wistar rats (ovary and brain)

Authors

  • Dali Ouzna Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Zouba Mouad Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Sebti Baghded Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Mai Hichem Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Bouazza Sofiane Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Dellal Abbes Department of Environment, Faculty of Natural Science and Life-Djilali Liabes University Sidi Bel Abbes, Algeria
  • Bekhadda Hadjer Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Ferrag Dalila Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • A. I. Benali Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Z. C. Khalloua Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria
  • Demmouche Abbassia Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi, Bel Abbes, Algeria

DOI:

https://doi.org/10.38150/sajeb.9(3).p114-123

Abstract

Mercury affects several organs and disrupts their functioning, and cinnamonis known for its antioxidant properties so in this study we evaluate the effectof cinnamon extract against the effect of mercury in ovary and brain. 20 female wistar rats were subdivided into four groups (01):received gavage andintraperitonial injection of physiological serum, (02): received gavage withphysiological serum and intraperitonial injection of HgCl2at dose of 0.25mg/Kg/BW/7days, (03): received gavage with hydroalcoholic extract of cinnamonat dose of 100mg/Kg/BW/7days and intraperitonial injection of physiologicalserum, (04): received gavage with hydroalcoholic extract of cinnamon atdose of 100mg/Kg/BW/7days and intraperitonial injection of HgCl2 at dose of0.25mg/Kg/BW/7days. Ovaries and brains were removed to weigh and prepared for histological study and blood were collected for hormonal study.The body weight increased significantly in the mercury-treated group (p =0.001) compared to the control group, a significant increase of left ovaries (p= 0.011) in the treated group with mercury compared to the other groups.The histological section on the brain of the mercury-treated group showsdiffuse cerebral fibrosis. Histological study shows an irregular developmentof ovarian follicles and an increase of atretic follicles in mercury treatedgroup, and cinnamon protect the ovary from the oxidative damage ofmercury. Cinnamon has protective effects against inflammation and oxidative stress in ovarian tissue and brain.

Author Biographies

Dali Ouzna, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Zouba Mouad, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Sebti Baghded, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Mai Hichem, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Bouazza Sofiane, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Dellal Abbes, Department of Environment, Faculty of Natural Science and Life-Djilali Liabes University Sidi Bel Abbes, Algeria

Department of Environment, Faculty of Natural Science and Life-Djilali Liabes University Sidi Bel Abbes, Algeria

Bekhadda Hadjer, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Ferrag Dalila, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

A. I. Benali, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria


Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi
Bel Abbes, Algeria

Z. C. Khalloua, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi, Bel Abbes, Algeria

Demmouche Abbassia, Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi, Bel Abbes, Algeria

Biotoxicology Laboratory, Department of Biology, Faculty of Natural Science and life, Djillali Liabes University; Sidi, Bel Abbes, Algeria

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Published

2019-10-10

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Research Articles