Impact of environments factors in reproductive function: Protective effect of cinnamon against the mercury chloride induced toxicity in female Wistar rats (ovary and brain)

Abstract

Mercury affects several organs and disrupts their functioning, and cinnamonis known for its antioxidant properties so in this study we evaluate the effectof cinnamon extract against the effect of mercury in ovary and brain. 20 female wistar rats were subdivided into four groups (01):received gavage andintraperitonial injection of physiological serum, (02): received gavage withphysiological serum and intraperitonial injection of HgCl2at dose of 0.25mg/Kg/BW/7days, (03): received gavage with hydroalcoholic extract of cinnamonat dose of 100mg/Kg/BW/7days and intraperitonial injection of physiologicalserum, (04): received gavage with hydroalcoholic extract of cinnamon atdose of 100mg/Kg/BW/7days and intraperitonial injection of HgCl2 at dose of0.25mg/Kg/BW/7days. Ovaries and brains were removed to weigh and prepared for histological study and blood were collected for hormonal study.The body weight increased significantly in the mercury-treated group (p =0.001) compared to the control group, a significant increase of left ovaries (p= 0.011) in the treated group with mercury compared to the other groups.The histological section on the brain of the mercury-treated group showsdiffuse cerebral fibrosis. Histological study shows an irregular developmentof ovarian follicles and an increase of atretic follicles in mercury treatedgroup, and cinnamon protect the ovary from the oxidative damage ofmercury. Cinnamon has protective effects against inflammation and oxidative stress in ovarian tissue and brain.