5-Phenyl-1, 2, 4-Triazole- 3- Thiol subchronic exposure induce neuro-comportemental desorder in Wistar rats

Abstract

Triazole and its derivatives possess a great importance in medicinal chemis-try with different biological effects; antiviral, antifungical, antibacterial and analgesic. The purpose of the present work is to assess the effects of 5 phe-nyl 1,2,4 Traizole 3 thiol (5 PTT) through a neurobehavioral exploration in Wistar rats. 5 PTT exposured rats showed increased body weight and brain weight. The open field test revealed a significant decrease in the number of crossed squares. However, the results related to the forced swimming test present a significant rise in the immobility time compared to the vehicle group. Furthermore, the Y maze test show that exposure to 5 PTT is associated with impairment of spatial learning performance and memory deficit is explained by a significant increase of the percentage of spontaneous alterna-tion in the exposed animals, the plus maze test revealed that 5 PTT admin-istrations reduced significantly the open arms time. Histological brain analy-sis show an alteration of tissue architecture and perivascular palisade in treated rats compared to vehicle rats. Our study demonstrated that 5 PTT exposures can cause neurotoxic effects that disrupt spatial learning and memory performance and induce a depressive state which reflects an altera-tion of the neurodevelopment process.