Tartrazine induced oxidative damage in mice liver and kidney

Authors

  • Latifa Alioui Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria
  • Nabila Mehedi Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria
  • Bouhada Youcef Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria
  • Omar Kheroua Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria
  • Djamel Saidi Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

DOI:

https://doi.org/10.38150/sajeb.7(6).p271-278

Abstract

Tartrazine is an azo dye which is widely used as colorant in foods, drugs and cosmetics.The aim of this study was to investigate the effect of tartrazine on biochemical and oxidative stress biomarkers on Swiss mice. Tartrazine was administered in drinking water at doses of 0%, 0.005% and 0.05% for 90 days. Both doses of tartrazine declined the body weight gain. In contrary, high dose increased glucose, total cholesterol (TC), triglycerides (TG), LDL, LDL/HDL and CT/HDL, transaminases, total protein (TP), total and direct bilirubin, , urea, creatinine, sodium and potassium levels. However, high dose of tartrazine decreased HDL, chloride, phosphorus and magnesium levels, whereas, tartrazine decreased calcium levels only in female. Both doses of tartrazine declined total antioxidant capacity. Protein carbonyls were in-creased in liver and kidney whith high dose. Liver and kidney superoxide dismutase (SOD) was decreased in male at low and high doses. However, liver SOD was reduced only in female at high dose. Oral administration of tartrazine affects liver and kidney functions as well as induces oxidative stress in mice. So, tartrazine consumption might be harmful to human health. It is necessary that people should be carefully consumed foods containing tartrazine.

Author Biographies

Latifa Alioui, Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria

Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria

Nabila Mehedi, Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

Bouhada Youcef, Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria

Laboratory of Physical Chemistry of Macromolecules and Biological Interfaces, Faculty of Sciences, Department of Biology, University of Mascara, Mascara, Algeria

Omar Kheroua, Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

Djamel Saidi, Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Physiology of Nutrition and Food Safety, Faculty of Sciences, University Oran 1 Ahmed Ben Bella, Oran, Algeria

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Published

2018-10-16

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Section

Research Articles