Algerian Anacyclus pyrethrum aqueous extract: novel antioxidant and neuroprotectant activity of a chemically profiled aqueous extract

Authors

  • Hassiba Yahiaoui University of Abdelhamid Ibn Badis BP 227, Mostaganem 27000, Algeria
  • Melanie-Jayne Howes Jodrel Labroatory, Kew Gardens, Royal Botanic Gardens, Richmond, TW9 3AE, UK
  • Samuel Ohiomakhare Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK
  • Ahmed M’Hamedi Chemistry Department, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, 11942, Al Kharj, Saudi Arabia
  • Paul L Chazot Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK

DOI:

https://doi.org/10.38150/sajeb.7(6).p262-270

Abstract

Anacyclus pyrethrum (L.) Lag has a long tradition of medical use in Algeria. We report for the first time the antioxidant, functional and neuroprotective properties of this plant from Algeria. Differences in biochemical and physiological properties for the aqueous and methanol extracts of A. pyrethrum are reported and related to the main chemical constituents. The A. pyrethrum extracts contained amino acids, caffeoylquinic acids, N-feruloyltyramine and alkaloids, including including N-alkylamides, common in this plant species. Aqueous extracts (0.1 mg/ml) are neuroprotective against H2O2-induced oxidative stress, while methanol extracts (high phenolic content), despite significant antioxidant and free-radical scavenging activity, caused dysregulation of calcium signalling in neurons and was not apparently neuroprotective. Such knowledge can provide incentive for the sustainable cultivation of Algerian A. pyrethrum, with the aim of supporting conservation strategies and preserving biodiversity.

Author Biographies

Hassiba Yahiaoui, University of Abdelhamid Ibn Badis BP 227, Mostaganem 27000, Algeria

University of Abdelhamid Ibn Badis BP 227, Mostaganem 27000, Algeria

Melanie-Jayne Howes, Jodrel Labroatory, Kew Gardens, Royal Botanic Gardens, Richmond, TW9 3AE, UK

Jodrel Labroatory, Kew Gardens, Royal Botanic Gardens, Richmond, TW9 3AE, UK

Samuel Ohiomakhare, Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK

Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK

Ahmed M’Hamedi, Chemistry Department, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, 11942, Al Kharj, Saudi Arabia

Chemistry Department, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, 11942, Al Kharj, Saudi Arabia

Paul L Chazot, Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK

Department of Biosciences, Durham University, South Road, Durham, DH13LE, UK

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Published

2018-10-16

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Section

Research Articles