Role of serotonin and noradrenalin in mechanisms of hypothalamic reg-ulation of experimental dystrophy of the retina

Authors

  • Miryusifova Ch. M. Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan
  • Mohammadova S. I. National Ophthalmology Center named after Z. A. Aliyeva, Laboratory of Pathology and Bacteriology, Baku, Azerbaijan
  • Azizov A. A. Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan
  • Mammadov Z. G. Department of Animal and Human Physiology, Baku State University, Baku, Azerbaijan

DOI:

https://doi.org/10.38150/sajeb.5(4).p137-142

Abstract

 

The features of the influence of electrical stimulation of the monoaminergic (MA) nuclei of the brain (nR, LC) on effects of the hypothalamic regulation of retinal electrogenesis in condition of experimental retinal dystrophy were studied It is shown that electrical stimulation of the suprachiasmatic nucleus of the hypothalamus (SCH) for 10 days on the background of the destruction of the pigment epithelium leads to the restoration of parameters as electro-retinogramm (ERG) and of the capacities of various structures of the visual analyzer. However, these effects are of short duration and quickly leveled. Preview activation of the various components MA-ergic system of the brain tends to have mixed influence of the effects of hypothalamic regulation. It is shown that the stimulation of nR increases the effects of SCH nuclei of the hypothalamus. In this environment, the recovery of the amplitude of the parameters from recommendation to photostimulation are stored during the time of testing (12 days). In contrast, stimulation of the LC leads to the oppo-site effects. In the current study, we discuss possible mechanisms of MA-ergic neuromodulation of plasticity of the various components of the visual system of the brain.

Author Biographies

Miryusifova Ch. M., Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan

 

Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan

Mohammadova S. I., National Ophthalmology Center named after Z. A. Aliyeva, Laboratory of Pathology and Bacteriology, Baku, Azerbaijan

 

National Ophthalmology Center named after Z. A. Aliyeva, Laboratory of Pathology and Bacteriology, Baku, Azerbaijan

Azizov A. A., Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan

 

Laboratory of Neurophysiology, Institute of Physiology of Nat. Acad. Sci., Baku, Azerbaijan

Mammadov Z. G., Department of Animal and Human Physiology, Baku State University, Baku, Azerbaijan

Department of Animal and Human Physiology, Baku State University, Baku, Azerbaijan

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Published

2015-12-22

Issue

Vol. 5 No. 4 (2015)

Section

Research Articles