Evaluation and correlation among T2DM patient with and without micro and macrovascular changes with various biochemical parameters

Abstract

Serum insulin level and insulin resistance are the prominent precursors of type 2 diabetes mellitus and HbA1c level correlates favorably with glycemic level. Obesity and dietary macronutrients also apparently play a role in this disease. Hence, insulin resistance, HbA1c, lipid profile and Magnesium level were evaluated in T2DM subjects categorized as having macro and micro-vascular complications and results were compared with controls. 200 sub-jects, grouped as- group I (50 normal healthy controls) ,Group- II (75 patients without any complication) and Group- III (75 patients having micro or macrovascular complications) were selected for this research study. We observed the fasting blood glucose level, serum HbA1c level, serum insulin level, insulin resistance, magnesium level and lipid profile in all group subjects. Significant increase in serum fasting glucose (p<0.001), insulin level (p<0.001) and re-sistance (p<0.001) was observed in both group II and Group III subjects when compared with control group. . HbA1c (%) level were recorded very high in both study group patients (p<0.01 and p<0.001). Serum magnesium level was measured and study group diabetic patients showed hypomagnesemia (p<0.01). Statistically highly significant value of Serum total cholesterol (p<0.001), triglyceride (p˂ 0.01) and LDL-C (p<0.001) were observed in both group subjects when compared with controls. Whereas statistically signifi-cantly decreases in serum HDLC (p<0.001) level were evaluated. Significant correlation coefficient with determination among diabetic group II and III patients and various biochemical parameters were evaluated. Hypomagnesemia and a higher level of cholesterol and TG values are responsible for macro-vascular changes in T2-DM.