Pattern of Hypothyroidism with Liver Cirrhosis among Indian population

Abstract

The thyroid plays a vital role in the overall body function during all stages of life. Although relatively small, it produces hormones that regulate the body’s overall metabolism ,the rate at which the body produces energy from nutri-ents. Thyroid hormones influence growth and development, oxygen con-sumption and heat production, nerve function and metabolism of lipids , carbohydrates ,proteins, nucleic acids ,vitamins and inorganic ions. Cirrhosis and chronic liver failure are leading causes of morbidity and mortality in the whole the world-with the majority of preventable cases attributed to exces-sive alcohol consumption, viral hepatitis or nonalcoholic fatty liver disease. The main objective of the study is to assess the relationship and interconnec-tion between hypothyroidism and chronic liver disease specially cirrhosis patients. All patients selected for this study were diagnosed as type of cir-rhosis in the line with the criteria set up by WHO. The study is comparative study containing two groups (1) cases and (2) controls. The result showed that TSH increased, T3 slightly decreased and T4 seems normal where the P value is 0.039,0.014 and 0.245 respectively. The mean of TSH levels of cir-rhotic patients is higher than the mean of non cirrhotic subjects and show significant difference. And also there are significant difference for T4 and T3 between two groups.