Gentamicin-embedded Nanocomposite Patches: A promising transdermal strategy for breast cancer therapy

Abstract

Breast cancer treatment remains challenging due to poor tumour targeting, systemic toxicity, and multidrug resistance. Gentamicin, primarily known as an antibiotic, has demonstrated anticancer properties but suffers from poor bioavailability and dose-limiting nephrotoxicity. Incorporating gentamicin into nanocomposite-based transdermal patches offers a promising strategy to overcome these limitations. This review highlights the formulation, characterization, and therapeutic potential of gentamicin-loaded nanocomposites for breast cancer treatment. Advantages include enhanced drug stability, controlled release, improved skin penetration, and reduced systemic exposure. In vitro cytotoxicity studies indicate significant anticancer activity against breast cancer cell lines. While challenges remain, this approach holds considerable potential for localized, sustained, and patient-compliant breast cancer therapy.