Assessment of Qualitative and Quantitative Parameters of Siddha Antipyretic Drug Astabhairava Mathirai based on PLIM Guidelines

Raghavi Marimuthu; Abarna  Balasubramani; Karpagambal  Ramamoorthy; Suresh Ramasamy; Haritha  Seshan; Sathish Adithya  Rajathinakaran; Madhavan  Ramachandran

doi:10.38150/sajeb.15(3).p121-130

Authors

Raghavi Marimuthu PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr. M. G. R Medical University), Ministry of Ayush, Chennai, Tamil Nadu, India. https://orcid.org/0009-0006-5537-1310
Abarna Balasubramani PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0005-1157-7205
Karpagambal Ramamoorthy PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0006-8481-1186
Suresh Ramasamy PG Scholar, Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0004-9403-0629
Haritha Seshan Department of Siddha Maruthuva Adipadai Thathuvangalum Varalarum, Sivaraj Siddha Medical College, Salem (Affiliated with The Tamil Nadu Dr. M. G. R Medical University), Ministry of Ayush, Chennai, Tamil Nadu, India
Sathish Adithya Rajathinakaran Assistant Professor, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0000-0002-4049-9454
Madhavan Ramachandran Professor, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0002-2777-5191

DOI:

https://doi.org/10.38150/sajeb.15(3).p121-130

Keywords:

Astabhairava Mathirai, PLIM Guideline, Antipyretic drug, Siddha medicine, Standardization

Abstract

According to Siddha pathology fever is classified as 64 types based on origin. Astabhairava Mathirai (ABM) is a Siddha metallo-mineral formulation traditionally used to treat 64 types of fever. Despite its historical significance, scientific validation of its safety is crucial for its acceptance in modern medicine. This study aims to assess the quality parameters of Asta bhairava mathirai based on PLIM Guidelines. The Astabhairava Mathirai was subjected to physiochemical analysis, Biochemical analysis, HPTLC and safety analysis like aflatoxin, pesticide residue, Microbial contamination, and heavy metals. The physicochemical analysis showed total ash (6.76%), acid-insoluble ash (1.14 %), pH (3.23), friability (0.020%), Water Extractive (26.95%), Alcohol Extractive (32.84%), hardness (1.0 kg/cm2), disintegration time (45 minutes). The biochemical analysis showed the presence of sulphide, sodium, iron, calcium, reducing sugar, and alkaloid. The safety studies viz., aflatoxin, pesticide residue, microbial contamination and heavy metals analysis revealed that the test drug ABM is within the AYUSH permissible limits. The HPTLC analysis showed the presence of 10 versatile phytochemical. Thus, the study reveals that the Astabhairava Mathirai has significant quality and safety. Consequently, these parameters can serve in the study of Astabhairava Mathirai as an important Siddha medicinal preparation among the scientific forum.