Scientific Validation and Quality Assurance of Muthuchippi Parpam at Sequential processing stages through Physicochemical, Biochemical and Phytochemical

Abarna Balasubramani; Raghavi  Marimuthu; Karpagambal  Ramamoorthy; Suresh  Ramasamy; Uthaya Ganga Rengan

doi:10.38150/sajeb.15(3).p81-89

Authors

Abarna Balasubramani PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0005-1157-7205
Raghavi Marimuthu PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0006-5537-1310
Karpagambal Ramamoorthy PG Scholar, Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0006-8481-1186
Suresh Ramasamy PG Scholar, Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, (Affiliated with The Tamil Nadu Dr.M.G. R Medical University) Ministry of Ayush, Chennai-47, Tamil Nadu, India. https://orcid.org/0009-0004-9403-0629
Uthaya Ganga Rengan

DOI:

https://doi.org/10.38150/sajeb.15(3).p81-89

Keywords:

Muthuchippi parpam, Marine derivative, Purification, Standardization, Siddha medicine

Abstract

The marine ecosystem has become a treasure trove for the discovery of new pharmacological leads, with oysters being a prime example. Abundant in protein and widely available, oysters have drawn significant attention. Interestingly, their shells, which account for approximately 60% of their total weight, are mainly composed of calcium carbonate (CaCO₃), making up a remarkable 95% of the shell's makeup. Muthuchippi parpam is a traditionally used Siddha formulation effective in the treatment of various diseases. The aim of the study is to evaluate the significant changes during processing of Muthuchippi parpam (at various stages of processing) as per PLIM guidelines by assessing the organoleptic, physico-chemical, biochemical properties of Muthuchippi across different stages: unpurified, purified, intermediate, and Parpam and phytochemical analysis of Muthuchippi parpam. Significant changes were observed in color, moisture content, ash values, extractive values, and pH, indicating the impact of purification and processing. The loss on drying remained below 1%, ensuring low moisture content and extended shelf life. Total ash content increased, reflecting higher mineral concentration in the purified and Parpam samples. Water-soluble and acid-insoluble ash values confirmed the purity of the final product. The pH increased from 7.56 to 9.80, highlighting its alkaline nature, beneficial in neutralizing stomach acid. Extractive values showed variations, suggesting changes in bioactive compounds during processing. The study demonstrates the changes taking place during various stages of processing thus it help in improving the stability, purity, and therapeutic promise of Muthuchippi Parpam, aligning with its established role in Siddha medicine.