South Asian Journal of Experimental Biology, Vol 1, No 5 (2011)

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Aug 11
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Immunomodulating effects of aqueous and methanol extracts of Jatropha curcas L. on haematological indices in Schistosoma haematobium – infected mice

Y Labe, H I Inabo, S E Yakubu

Abstract


The haematological indices of

 

S. haematobium – infected Swiss Albino mice

were monitored to evaluate the immunomodulatory activities of aqueous

(AJc) and methanol (MJc) extracts of

 

Jatropha curcas (L.) at pre‐infection

post

 

‐infection and post‐treatment. There was a non‐significant decrease

(p>0.05) in the weight of mice in all the groups. However, there was significant

increase (

 

p < 0.05) in the total white blood cell counts, neutrophils and

lymphocytes for group I (AJc) and group II (MJc) in

 

S. haematobium ‐ infected

mice. There was no relationship between the level of eosinophils in the

treated mice. No significant change in the haematological indices was observed

in the group which was administered the standard drug

 

‐ Praziquantel

(PZQ). The immunomodualting effects of aqueous and methanol extracts of

Jatropha curcas

 

 

Schistosoma haematobium

‐

 

‐

‐

infected mice.
when compared to PZQ are promising in immunosuppressed

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